Neospora caninum: Structure and Fate of Multinucleated Complexes Induced by the Bumped Kinase Inhibitor BKI-1294
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چکیده
منابع مشابه
Bumped kinase inhibitor 1294 treats established Toxoplasma gondii infection.
Toxoplasma gondii is a unicellular parasite that causes severe brain and eye disease. Current drugs for T. gondii are limited by toxicity. Bumped kinase inhibitors (BKIs) selectively inhibit calcium-dependent protein kinases of the apicomplexan pathogens T. gondii, cryptosporidia, and plasmodia. A lead anti-Toxoplasma BKI, 1294, has been developed to be metabolically stable and orally bioavaila...
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Despite the enormous economic importance of Neospora caninum related veterinary diseases, the number of effective therapeutic agents is relatively small. Development of new therapeutic strategies to combat the economic impact of neosporosis remains an important scientific endeavor. This study demonstrates molecular, structural and phenotypic evidence that N. caninum calcium-dependent protein ki...
متن کاملthe underlying structure of language proficiency and the proficiency level
هدف از انجام این تخقیق بررسی رابطه احتمالی بین سطح مهارت زبان خارجی (foreign language proficiency) و ساختار مهارت زبان خارجی بود. تعداد 314 زبان آموز مونث و مذکر که عمدتا دانشجویان رشته های زبان انگلیسی در سطوح کارشناسی و کارشناسی ارشد بودند در این تحقیق شرکت کردند. از لحاظ سطح مهارت زبان خارجی شرکت کنندگان بسیار با هم متفاوت بودند، (75 نفر سطح پیشرفته، 113 نفر سطح متوسط، 126 سطح مقدماتی). کلا ...
15 صفحه اولNeospora caninum and neosporosis
Neospora caninum is a protozoan cyst forming apicomplexan parasite that causes neosporosis, notably in cattle (Bos taurus) and domestic dogs (Canis familiaris) [1,2]. It is closely related to Toxoplasma gondii and has emerged as a major cause of reproductive failure in cattle worldwide [2]. The parasite was first described in a dog with encephalomyelitis and myositis [1] and was later described...
متن کاملNeospora caninum and Wildlife
Bovine neosporosis caused by Neospora caninum is among the main causes of abortion in cattle nowadays. At present there is no effective treatment or vaccine. Serological evidence in domestic, wild, and zoo animals indicates that many species have been exposed to this parasite. However, many aspects of the life cycle of N. caninum are unknown and the role of wildlife in the life cycle of N. cani...
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ژورنال
عنوان ژورنال: Pathogens
سال: 2020
ISSN: 2076-0817
DOI: 10.3390/pathogens9050382